We have an exciting new opportunity for a skilled and diligent Research Scientist to join our dynamic Phage Platform team.

You will enjoy a varied and rewarding role working in a multi-disciplinary environment to develop and deploy our proprietary technology. The role will involve providing essential support to Bicycle’s early drug discovery efforts by identifying Bicycle binders to targets of interest.  The role will also involve significant cross-functional collaboration to deliver technology and process improvements.

you will be a highly motivated, methodical, well-organised individual who enjoys working at the bench. Previous experience in a multi-disciplinary lab utilizing molecular biology, biochemical and biophysical techniques is essential. Experience of working with phage or other display technologies is desirable but not required. The role would suit someone looking for a high degree of hands-on practical work where their efforts can impact broadly.

This opportunity allows meaningful contribution to our efforts in finding new life-changing drugs.

Key responsibilities

• Plan, execute and troubleshoot phage display campaigns using  proprietary Bicycle platform
  • Phage panning, library design, sequencing (Sanger & NGS)
  • Characterise Bicycle binders identified, e.g. AlphaScreen/ELISA, SPR, flow cytometry
  • Interpret structure activity relationships to inform chemical optimisation
• Design, test and implement innovations to platform technology
  • Stay up to date with current literature in the area, seek ideas from internal and external sources to bring about process/technology evolution
  • Facilitate adoption through stakeholder engagement and rigorous validation
• Generate robust data packages to support project milestones
• Accurate and timely record keeping via electronic lab notebook system (Dotmatics)
• Analyse and present complex data to internal and external stakeholders
• Willing to take on additional responsibilities outside of core role such as EH&S roles, being “super user” for lab equipment etc.