Our client, a biopharmaceutical company based near Cambridge, is looking for a Scientist (T-Cell Engineering) to join their growing research team.

Candidates should be comfortable with a fast-paced, dynamic working environment and hold good communication skills to facilitate the necessary close interactions with the internal teams as well as external partners.

KEY RESPONSIBILITIES:

• Planning and execution of a wide range of robust experiments, technical studies, and tasks, working independently based on protocols and in line with departmental objectives.
• Assaying of our client’s engineered delivery vehicle using flow cytometry, western blot, ELISA, and immunofluorescence.
• Inform and implement the design of novel genetic constructs for use in T Cell engineering.
• Development of robust T Cell engineering platform.
• Development of T Cell functionality assays.
• Cell culture (propagation, banking, characterisation) of cell lines and primary cells.
• Timely, accurate recording and analysis of results and compliance with data integrity procedures.
• Timely presentation of data to the department and wider company.
• Contribution to critical interpretation of data to draw results driven hypotheses, with influence on project/function direction.

It is essential that candidates have the following skills and experience:

• A PhD with experience in T Cell biology (or equivalent experience gained in industry). Engineering of T Cells for the purpose of CAR-T generation with Lentiviral or CRISPR based systems is a plus.
• Experience handling and culturing a range of cell lines.
• Experience with CRISPR based editing of primary human T Cells, both KO and KI
• Experience with genetic approaches for quantifying T Cell engineering outcomes.
• Experience with assays of T Cell functionality and potency, especially in the context of CAR-T.
• Strong experience with flow cytometry-based assays.
• Experience with single cell sequencing assay.
• Fluency in spoken and written English.
• Proficiency with critical interpretation of data and implementation into an experimental cascade.
• Communication in a clear, well-structured, and professional manner with key stakeholders within the company on a regular basis.
• Contribution to authoring of technical and science reports which will feed into IND filings.
• Awareness of latest scientific literature in company-relevant projects and general scientific areas.